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Twice daily application is usually unnecessary, the enhanced permeability means you're getting adequate penetration from single application
Definitions and History The term insert refers a semi-solid pharmaceutical dosage form carrying active pharmaceutical ingredients (APIs) dispersed in a base that melts at body temperature or dissolves, applied by placing into naturally occurring body cavities aside from the mouth or rectum, such as the vagina (1)
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Lysyl oxidase Copper-dependent enzyme that catalyzes the oxidative deamination of lysine residues in collagen and elastin, producing aldehydes that participate in cross-linking reactions essential for mature extracellular matrix mechanical properties
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